Multiple sequence alignment with user-defined anchor points
نویسندگان
چکیده
منابع مشابه
Multiple sequence alignment with user-defined constraints
In many situations, automated multi-alignment programs are not able to correctly align families of nucleic acid or protein sequences. Difficult cases comprise not only distantly related sequences but also tandem duplications independent of their evolutionary age. Frequently, additional biological information is available that establishes homologies at least in parts of the sequences based on st...
متن کاملMultiple sequence alignment using anchor points through generalized dynamic programming
A generalization of the dynamic programming algorithm applied to the multiple alignment of protein sequences is proposed. The algorithm has two main procedures: (i) local correspondences between sequences hereafter called anchor points are selected according to a criterion that combines local and global simlilarity values, (ii) the alignment is constructed recursively by choosing and linking to...
متن کاملMultiple sequence alignment with user-defined constraints at GOBICS
Most multi-alignment methods are fully automated, i.e. they are based on a fixed set of mathematical rules. For various reasons, such methods may fail to produce biologically meaningful alignments. Herein, we describe a semi-automatic approach to multiple sequence alignment where biological expert knowledge can be used to influence the alignment procedure. The user can specify parts of the sequ...
متن کاملMultiple sequence alignment with user-defined constraints @ GOBICS
Summary: Most multi-alignment methods are fully automated, i.e. they are based on a fixed set of mathematical rules. For various reasons, such methods may fail to produce biologically meaningful alignments. Herein, we describe a semi-automatic approach to multiple sequence alignment where biological expert knowledge can be used to influence the alignment procedure. The user can specify parts of...
متن کاملMultiple Sequence Alignment Multiple Sequence Alignment
An algorithm for progressive multiple alignment of sequences with insertions " , 1. Introduction The problem of sequence alignment is to find the patterns of sequence conservation and similarity between pairs or sets of given sequences. In biological contexts, similarity between biological sequences usually amounts to either functional or structural similarities or divergence from a common ance...
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ژورنال
عنوان ژورنال: Algorithms for Molecular Biology
سال: 2006
ISSN: 1748-7188
DOI: 10.1186/1748-7188-1-6